منابع مشابه
Bronchial secretion levels of amikacin.
Amikacin was given to 14 noninfected men as three consecutive intramuscular injections (7.5 mg/kg) at 12-h intervals. Serum and bronchial secretion specimens were obtained at various times during flexible fiberoptic bronchoscopy after the final dose. Serum and bronchial secretion concentrations obtained between 1.5 and 2.0 h after the final dose ranged from 17 to 40 mug/ml and 2.3 to 8.4 mug/ml...
متن کاملIntraventricular levels of amikacin after intravenous administration.
Serum and ventricular fluid pharmacokinetic data for amikacin were evaluated prospectively in 10 hydrocephalic children with suspected ventriculitis. After the fourth or fifth intravenous 7.5-mg/kg dose of amikacin given every 8 h, mean peak serum levels were 24.3 +/- 3.2 microgram/ml (achieved at 0.5 h) with a calculated half-life of 2.2 +/- 1.1 h. Mean peak ventricular fluid levels in five pa...
متن کاملThe viscosity of bronchial secretion.
1. The viscosity of sputum in patients with chronic bronchitis has been measured with the Weissenberg rheogoniometer, a cone and plate system, using oscillatory movement at low shear rates. 2. A characteristic pattern is described not previously reported for sputum or any other biological fluid. 3. Sputum viscosity decreased steadily with increasing shear rate; over a narrow range of shear rate...
متن کاملClinical Pharmacokinetics of Amikacin in Neonates
Amikacin is a bactericidal aminoglycoside. Aminoglycosides inhibit bacterial protein synthesis. The antibacterial spectrum of amikacin is the broadest of aminoglycosides. Because of its resistance to many of the aminoglycosides-inactivating enzymes, it has a special role in hospitals where gentamicin- and tobramycin-resistant microorganisms are prevalent. Amikacin is active against the majority...
متن کاملMechanism of substance P-induced liquid secretion across bronchial epithelium.
The present study was undertaken to identify and determine the mechanism of noncholinergic pathways for the induction of liquid secretion across airway epithelium. Excised porcine bronchi secreted substantial and significant quantities of liquid when exposed to acetylcholine, substance P, or forskolin but not to isoproterenol, norepinephrine, or phenylephrine. Bumetanide, an inhibitor of Na(+)-...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1979
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.16.6.767